Cognitive / neuroprotection research
Limited Human Evidence
Region-specific clinical use and research exist. Not an FDA-approved nootropic.
Also known as ACTH(4-10) analog
Synthetic ACTH fragment analog studied as a nootropic/neuroprotective candidate in some countries. Not FDA-approved.
Semax is a synthetic analog of a fragment of adrenocorticotropic hormone. It has been investigated for cognitive and neuroprotection hypotheses, including intranasal use in some research settings. It is not FDA-approved.
Semax is a lab-made relative of a small piece of ACTH, designed not as a steroid-stimulating hormone course but as a CNS research peptide.
Nootropic marketing online is stronger than the independently reviewed U.S. evidence base.
Semax is based on a snippet of a pituitary hormone. Researchers have explored whether it changes brain growth-factor and transmitter signals. That research is not the same as an approved U.S. cognitive drug.
ACTH fragment analogs have been investigated for melanocortin-independent CNS effects, including BDNF-related hypotheses. Exact clinical mechanism and effect size in generalizable trials remain insufficiently established for U.S. practice.
Step 1
Peptide
Semax
Step 2
Proposed targets
CNS signaling hypotheses (including neurotrophic pathways)
Step 3
Pathway
Experimental neuroprotection/cognition models
Step 4
Observed research effect
Investigational; not FDA-established
Region-specific clinical use and research exist. Not an FDA-approved nootropic.
Human studies exist in some literature. They are not presented here as FDA-established indications.
BDNF and monoamine-related hypotheses appear in research summaries; primary papers should be read before any strong mechanistic claim.
No sourced study cards have been attached yet. Information not sufficiently established at the study-card level.
Safety information may be incomplete, especially for experimental peptides.
Safety information may be incomplete, especially for experimental peptides. Consult a qualified healthcare professional for personal medical advice.
Long-term safety: Not sufficiently established.
Evidence limitations: Language and publication-bias issues can affect this literature.
Administration practices vary by compound and clinical context. Follow approved prescribing information or guidance from a qualified healthcare professional. This page does not provide injection technique, mixing, or personalized dosing instructions.
These are unofficial community figures from the reconstitution calculator, used only so vial milligrams convert into U-100 units. They are not a personal Semax dose and not approved labeling.
Semax
100 mcg, 300 mcg
Open the peptide reconstitution calculator for Semax, including mix volume and syringe units.
Discovery
complete
ACTH fragment analog.
Human studies
in progress
Region-specific literature.
Regulatory status
not started
Not FDA-approved.
No. It is not FDA-approved.
Neurological Research
Synthetic tuftsin-derived heptapeptide studied for anxiolytic and nootropic hypotheses, including work outside the U.S. Not FDA-approved.
View peptide →